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It’s particularly helpful for Parkinson’s and schizophrenia patients who also have depression (14).
SAM-e should not be mixed with drugs that affect serotonin release such as levodopa, Demerol, or Ultram, or the over-the-counter cough remedy Robitussin DM (15).
But SSRIs can have serious side effects and don’t work for everyone, possibly up to 40 percent of those who try them (1).
Some research shows they work no better than a placebo (2).
A review of 108 studies on 5-HTP revealed there is still no definitive evidence that it helps depression (9). An Ongoing Debate: There’s an ongoing discussion in the natural health community whether it’s better to take tryptophan or 5-HTP to increase serotonin levels.
Selective serotonin reuptake inhibitors (SSRIs) such as Paxil, Prozac, Zoloft, Celexa, and Lexapro are used by millions to relieve symptoms of depression by increasing brain levels of serotonin.5-HTP (5-hydroxytryptophan): 5-HTP could be considered as either an amino acid or herbal supplement.It comes from Griffonia simplicifolia, an African woody shrub. But we’ve put it in the amino acid category since it’s so closely associated with tryptophan. S., Canada, and the United Kingdom, 5-HTP is sold as an over-the-counter supplement for ADHD, anxiety, depression, fibromyalgia, migraines, sleep disorders, and weight loss (7).Before you take any serotonin supplement, it’s important to understand a little bit about them and especially how they work together.
Sometimes there are vital synergistic relationships between these various serotonin boosting substances.But since protein blocks serotonin synthesis, eating a meal containing protein will actually cause both tryptophan and serotonin levels drop.